We're discovering the unknown in inflammation
"During injury or infection, our body’s immune system protects us by launching inflammation. But uncontrolled inflammation drives diseases such as gout, diabetes, neurodegenerative disease and cancer."
– Professor Kate Schroder
Inflammation is a shapeshifter – our body's ancient response to injury and disease that can also be the cause of chronic diseases such as cancer, obesity, inflammatory bowel disease, asthma, arthritis and neurodegenerative diseases.
Inflammation is triggered when the body’s cells are infected or injured, and attracts immune cells to clear away any damaged or dead cells. But if the damaged or dead cells are not removed, the inflammation cycle continues, amplifying damage to the body and initiating disease as a consequence.
Our researchers are deconstructing the machinery of inflammation into its various parts – understanding the molecular mechanisms lighting its fire, what regulates it, how the process promotes the recovery of health and how and why the process can malfunction.
Our research leaders at the Centre for Inflammation and Disease Research are focused on making scientific breakthrough a reality in this space through developing new biomarkers and therapies to identify, prevent and treat the underlying causes of inflammatory diseases.
The promising developments of new anti-inflammatory treatments is transforming our small research steps into strides, hastening the guarantee of new therapeutics that will change the face of medicine and save the lives of many people in the 21st century.
Shining a light on: Kate Schroder
It was when working under Professor Jürg Tschopp that Kate became hooked on the biology of inflammasomes – inflammation-generating molecular machines that trigger immune cells to respond to an infection or injury.
“Inflazome is advancing the compounds with the aim of developing new treatments for inflammatory disease where there are significant unmet needs, such as Parkinson’s disease.”